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In 2002, before the destruction of the Russian branch of Umbrella. Leon is sent to a small South American country as part of a secret military detachment after the headquarters were informed that a former researcher from Umbrella contacted a man named Javier Hidalgo in a small South American state. Due to the difficult nature of the operation, Jack Krauser, a seasoned operative with a history of brave service, was selected to be Leon’s partner.

Krauser and Leon were sent on a mission by the U. S. government to infiltrate this small South American country. Finding Javier is their objective, since he is a drug lord who has taken de-facto control over a large area of jungle. He rules the entire area absolutely. The small government is unable to do anything about Javier’s control of the drug trade, so Krauser and Leon have been called in. The U.S. government has received information that a former Umbrella researcher has somehow entered the region. Sources indicate that something strange is going on, but no accurate information can be obtained. Unwilling to risk a biohazard incident, a secret military agency pairs Leon and Krauser and sends them into this volatile region to determine what, if anything, is going on.

They later find themselves having to cooperate as a two-man cell in a t-Virus outbreak. Leon also meets a mysterious girl called Manuela, that seems to be the only survivor of the village, though it is unknown why she didn't escape.

(http://residentevil.wikia.com/Leon_S._Kennedy)