Most Famous?

[KunoichiHyuga-Chan]

Ed/Roy
Naruto/Sasuke ( I don't like this one)
Harry/Draco ( I don't like this...)
Kakashi/Iruka
Itachi/Sasuke ( I don't like this either)
Cloud/Vincent
Riku/Sora
Gaara/Lee  

[Kaiju Koi]

LxLight, no doubt.  

[eduardo galpaleano]

ὄφις §

[now I'm of consenting age to be forgetting you in a cabaret]
[somewhere downtown where a burlesque queen may even ask my name]
[as she sheds her skin on stage]
[I'm seated and sweating to a dance song on the club's P.A.]
[the strip joint veteran sits two away]

»____.❤____.>

Harry/Draco.
I researched it once O_o.
Gaia Online, Livejournal, the Fanlistings, Fanfiction, y!gallery, Adultfanfiction, and a Google Fight.
Put it up against EVERYTHING - I have determined that it is THE most popular slash pairing in the world.
and TIED for the most popular PAIRING in the world.
Tied with InuYasha/Kagome - if you really cared to know.

Don't even ask what kind of life I lead.

<___.♥___.«

[smirking between dignified sips of his dignified peach and lime daiquiri]
[and isn't this exactly where you'd like me]
[I'm exactly where you'd like me, you know]
[praying for love in a lap dance and paying in naivety]
[oh, isn't this exactly where you'd like me]

§ ὄφις

 

[O r a l F ii x a t i o n]

Heero/Duo
Trowa/Quatre
Sora/Riku
Roxas/Axel
Cloud/Leon
Cloud/Sephiroth
Draco/Harry
Neji/Gaara
Roy/Ed
Yami/Yugi
L/Light
Mello/Near
Kyo/Yuki
Jack/Will
Ban/Ginji

 

[Ashira_Aria]

Hirama (Hiei x Kurama) I would say. Everywhere I look they are together. Well, kurama is very pairable, but another popular one with him is Karakura (Karasu x Kurama).  

[Andromeda3173]

JazzMasterGanon

Maybe Roy/Ed from FMA?

Gah! a hell yes!! to this and Duo/heero, Neji/Gaara, L/Light, Ban/Ginji and Sora/riku! ^^ xd gah! lol... i just LOVE those! xd heart heart  

[protecterofelements]

Sasuke x Naruto
Gaara x Naruto
Kakshi x Iruka
Harry Potter x Draco Malfoy
Sirius Black x Remus Lupin
Ed x Envy
Yuuri x Wolfram
Tezuki x Hisoka
Ryoma x Fuji  

[Scribraven]

What about CLAMP couples?

TouyaxYukito

SubxSess

KuroxFai

They've got huge followings, as well. Sasunaru and HarryxDraco are probably the biggest, though.  

[bullterrierlove]

KuroxFai
RoyxEd
TouyaxYukito
AxelxRoxas
LxLight

Those are the ones that I think that seem to be really popular.  

[otakubaybay]

JazzMasterGanon

Maybe Roy/Ed from FMA?

Have to agree 3nodding  

[Hoshi no Miko]

Mistress Ophiucha

ὄφις §

[now I'm of consenting age to be forgetting you in a cabaret]
[somewhere downtown where a burlesque queen may even ask my name]
[as she sheds her skin on stage]
[I'm seated and sweating to a dance song on the club's P.A.]
[the strip joint veteran sits two away]

»____.❤____.>

Harry/Draco.
I researched it once O_o.
Gaia Online, Livejournal, the Fanlistings, Fanfiction, y!gallery, Adultfanfiction, and a Google Fight.
Put it up against EVERYTHING - I have determined that it is THE most popular slash pairing in the world.
and TIED for the most popular PAIRING in the world.
Tied with InuYasha/Kagome - if you really cared to know.

Don't even ask what kind of life I lead.

<___.♥___.«

[smirking between dignified sips of his dignified peach and lime daiquiri]
[and isn't this exactly where you'd like me]
[I'm exactly where you'd like me, you know]
[praying for love in a lap dance and paying in naivety]
[oh, isn't this exactly where you'd like me]

§ ὄφις

Holy bejeebus! eek Are you serious?  

[ChaoticAngelofElvenBlood]

Mistress Ophiucha

ὄφις §

[now I'm of consenting age to be forgetting you in a cabaret]
[somewhere downtown where a burlesque queen may even ask my name]
[as she sheds her skin on stage]
[I'm seated and sweating to a dance song on the club's P.A.]
[the strip joint veteran sits two away]

»____.❤____.>

Harry/Draco.
I researched it once O_o.
Gaia Online, Livejournal, the Fanlistings, Fanfiction, y!gallery, Adultfanfiction, and a Google Fight.
Put it up against EVERYTHING - I have determined that it is THE most popular slash pairing in the world.
and TIED for the most popular PAIRING in the world.
Tied with InuYasha/Kagome - if you really cared to know.

Don't even ask what kind of life I lead.

<___.♥___.«

[smirking between dignified sips of his dignified peach and lime daiquiri]
[and isn't this exactly where you'd like me]
[I'm exactly where you'd like me, you know]
[praying for love in a lap dance and paying in naivety]
[oh, isn't this exactly where you'd like me]

§ ὄφις

You did all that? Well, you my friend are awesome! Here. You win the internet.  

[ranma064]

Harry/Draco <3  

[XxXMoonGoddessXxX]

LXLight  

[- A y u C h u -]

ChaoticAngelofElvenBlood

What slash pairing besides SasukexNaruto do you think has the most fandom in the yaoi world? I'm curious as to what all of you think.

yup